Lilly's two-drug weight-loss treatment cut 23% of body weight in people with diabetes, and up to 27% stopped taking it

The rest of the day

25 more stories on this beat.

Each with its own sources. None of these is a link to the story above.

1. 02

   US drug-price rule shrinks to four companies

   The Trump administration published the final version of GLOBE, a rule meant to cut what Medicare, the US government's health plan for older people, pays for drugs given in doctors' offices. [7] GLOBE ties those prices to what other rich countries pay. [7] Companies that signed separate voluntary price deals with the Trump administration are exempt, so the rule now covers only four companies, and it does not name them. [7] Medicare's own forecasters expect savings of $440 million, down from nearly $12 billion in the draft. [7]

   $12bnDraft rule

   vsvs

   $440mFinal rule

   Why it matters — The deals the Trump administration struck one company at a time now decide who escapes the rule. [7] A Harvard researcher who studied GLOBE said the smaller savings match his own estimate. [7]

2. 03

   Lilly's three-hormone drug: full results

   On Tuesday Eli Lilly gave full results for retatrutide, a weekly injection that copies three hormones, in Milan and in The Lancet, a medical journal. [4] In 1,152 adults with obesity and type 2 diabetes, the top dose cut weight by 20.8% over 80 weeks, against 4% on a dummy injection. [4] More than half on the top dose no longer counted as obese. [4] All three doses lowered A1C, the blood-sugar measure, by about the same amount, 1.4% to 1.6%. [4] Lilly plans to ask the FDA, the US drug regulator, for approval early next year. [4]

   Why it matters — Lilly now has two drugs aiming past its own Zepbound, and its executive Kenneth Custer said the new combination might beat retatrutide in later trials. [1]

3. 04

   A trial death raises liver questions

   Bristol Myers Squibb, a large US drugmaker, changed a final-stage trial of admilparant to watch more closely for liver damage, a spokesperson said on Wednesday. [8] Admilparant is an experimental drug for idiopathic pulmonary fibrosis, a disease that scars the lungs. [8] A limited number of liver problems were seen, and one participant died of multi-organ failure with liver damage. [8] It is not clear whether that person received the drug, and outside monitors have each time advised that the trial continue. [8] Results are due by the end of the year. [8]

   Why it matters — Bristol Myers dropped an earlier drug of the same type over liver damage, and shares in Contineum Therapeutics, which is testing a similar drug, also fell on Tuesday. [8]

4. 05

   FDA reviews Roche's multiple sclerosis pill

   The FDA agreed to review fenebrutinib, an experimental pill for multiple sclerosis from Roche, the Swiss drugmaker. [9] It could become the first drug of its type approved for both the relapsing form of the disease and the primary progressive form, which worsens steadily. [9] It met its main goals in three final-stage trials, and the review is on a six-month fast track. [9] But eight people taking it died across two of those trials, against one on the comparison drug. [9] Roche says the deaths happened at different times and had various causes. [9]

   Why it matters — Two rival pills of the same type, from Merck KGaA and Sanofi, were slowed by liver side effects, and Sanofi's was turned down in the US partly over safety. [9]

5. 06

   Legal immigrants lose US health cover

   From 1 October many immigrants living legally in the US lose Medicaid, the US government health plan for people on low incomes. [18] The change comes from the One Big Beautiful Bill Act, the 2025 law expected to cut Medicaid spending by more than $900 billion through 2034. [18] Refugees, people granted asylum and victims of sex trafficking are among those affected; green-card holders are not. [18] Nine states and Washington DC told KFF Health News that more than 281,000 people will lose cover this month, nearly 177,000 of them in Florida. [18]

   Why it matters — They can still get emergency care through a separate programme. [18] A change starting in January will also take help buying private cover from about a million immigrants by 2034, the Congressional Budget Office estimates. [18]

6. 07

   Merck stops selling a last-resort antibiotic

   Merck, one of the biggest US drugmakers, stopped supplying the antibiotic Recarbrio in the US earlier this month, STAT reported. [12] Recarbrio is a three-drug injection approved seven years ago for serious infections, such as pneumonia caught in hospital or on a ventilator. [12] The FDA marked it from the start as a treatment of last resort, to slow the spread of germs that resist antibiotics. [12] That also limited how much of it could be sold. [12] Merck did not explain its decision or disclose its sales. [12]

   Why it matters — It was used for adults and children with few or no other treatment options, which is the group that loses it. [12]

7. 08

   Roche's amylin drug peaks at the middle dose

   Roche and its Danish partner Zealand Pharma published fuller results for petrelintide, an experimental weekly injection that copies amylin, in a Lancet journal. [5] At 28 weeks, weight loss was 7.9% on the two lowest doses, 1 mg and 2.5 mg, and 9.8% on 5 mg. [5] The 7 mg and 9 mg doses did no better, at 9.3% and 9.4%. [5] Nausea hit 20% of people on the drug, against 6% on a dummy injection. [5] Roche was due to start three final-stage trials on Wednesday. [5]

   Why it matters — Roche paid $1.65 billion up front for the drug in 2025. [5] Comparisons across different trials suggest it will not lead on weight loss, so Roche and Zealand point to milder side effects instead. [5]

8. 09

   Switching from jabs to Novo's pill

   Novo Nordisk, the Danish maker of Wegovy, presented a study of 194 people who moved from weight-loss injections to its daily Wegovy pill. [6] Over three months they lost a further 4.1% of their body weight on average. [6] The share counted as obese fell from 87.1% to 65.5%. [6] Novo compiled the data with Ro, a US online clinic, and part of it is what patients reported themselves. [6] With no comparison group, the study cannot show that the pill caused the loss. [6]

   Why it matters — Novo's own presentations say pills now make up about a third of US obesity prescriptions, and that Novo takes more than 80% of new pill prescriptions. [6]

9. 10

   Beam sues a rival over gene-editing secrets

   Beam Therapeutics, a US company that edits single letters of DNA, sued a former scientist and two companies in a Massachusetts court on 25 September. [10] It says Zi Jun Wang secretly founded YolTech Therapeutics in China in 2021 while still working at Beam, and opened Beam files far outside her own work at night and on weekends. [10][11] Beam says YolTech's treatment for alpha-1 antitrypsin deficiency, an inherited disease, is strikingly similar to its own. [10] Serapha Bio, which licensed YolTech's treatment outside China, rejects the claims. [10]

   Why it matters — Serapha launched in June with $230 million. [10] The case lands amid rising tension between US and Chinese biotech companies. [10][11]

10. 11

    Merck's drug clears painful skin lumps

    Merck released results for tulisokibart in hidradenitis suppurativa, a long-lasting disease that causes painful lumps under the skin. [14] In a mid-stage trial of 149 people, 72% on the highest dose had at least half their lumps and abscesses go within 16 weeks, against 35% on a dummy injection. [13][14] The middle dose reached 64% and the low dose 52%. [13] Merck plans a final-stage trial. [13] It got the drug when it bought Prometheus Biosciences for $10.8 billion in 2023. [13]

    Dummy injection35%

    Low dose52%

    Middle dose64%

    High dose72%

    Why it matters — Merck is counting on drugs like this to help replace sales of Keytruda, its best-selling cancer drug, which loses its patent protection later this decade. [14]

11. 12

    Fewer return trips for a lung disease

    Connect Biopharma, a San Diego company, tested rademikibart in 159 people with COPD, a long-term lung disease, who had just had a flare-up. [16] Added to usual care, it cut the rate of treatment failure over four weeks by 81% against a dummy injection. [16] No one on the drug needed a hospital or emergency visit in that time. [16] It missed a goal on a breathing test after seven days. [16] A sister trial in asthma, reported weeks earlier, fell short. [16]

    Why it matters — Simcere, a Chinese drugmaker, paid $21 million for the China rights amid hopes it could rival Dupixent, the big-selling asthma and COPD drug from Sanofi and Regeneron. [16] Connect plans to ask the FDA about a final-stage trial. [16]

12. 13

    A lupus antibody works on skin sores

    Amgen, a large US biotech company, published results for daxdilimab in 72 people with discoid lupus, an immune disease that causes sores on the skin. [15] After 24 weeks about 62% on either dose had their disease score at least halved, against 23.7% on a dummy injection. [15] The lower dose did slightly better on the main skin score, cutting it by 6 points against 5.7 for the higher dose. [15] No serious side effects or deaths were reported. [15] The same antibody failed in 2023 in the more common form of lupus. [15]

    Why it matters — Amgen got the drug in its $27.8 billion purchase of Horizon Therapeutics, and is moving it towards the final stage of testing. [15]

13. 14

    An injection shrinks a common skin cancer

    Highlight Therapeutics, a Spanish company, injected its drug BO-112 straight into basal cell carcinoma in 46 patients. [17] Basal cell carcinoma is the most common skin cancer, usually found on the face, head, neck and arms. [17] After 24 weeks, 61% responded, judged both by eye and under the microscope. [17] In high-risk cancers of the head and neck, 56% had no cancer cells left in the tissue examined. [17] The trial had no comparison group. [17]

    Why it matters — Surgery is the usual treatment, and the company wants to offer this as a non-surgical option, especially for high-risk cancers on the head and neck. [17]

14. 15

    US moves against a strong kratom chemical

    Kratom is a Southeast Asian plant with opioid-like effects, sold in the US as a supplement in petrol stations and shops. [19] The DEA, the US drug-enforcement agency, has proposed temporarily listing 7-OH, a strong chemical from kratom, as Schedule I above a set strength. [20] Schedule I is for the riskiest drugs with no accepted medical use. [20] Pressure grew after kratom was found with two University of Mississippi students who died this month. [19][20] Authorities have not said that kratom caused either death. [20]

    Why it matters — Milder kratom leaf products would stay on sale, and 11 US states already ban kratom outright. [20][19]

15. 16

    Measles deaths: the CDC counts two, Pennsylvania four

    The CDC, the US public-health agency, updated its website to show two measles deaths in the US this year. [20] Pennsylvania, which is in a historic outbreak, counts four measles-related deaths of its own. [20] It is not clear which of those four the CDC added. [20] A University of Pennsylvania survey found 31% of US adults think Health Secretary Robert F. Kennedy Jr. recommends the measles vaccine for children, 29% think he does not, and 40% are unsure. [20]

    2 deathsCDC, whole US

    vsvs

    4 deathsPennsylvania alone

    Why it matters — Kennedy, the US health secretary, has made misleading claims about vaccines, STAT reports. [20]

16. 17

    Two charged over fake Ozempic

    A US grand jury charged two Indian nationals with smuggling and selling fake Ozempic, the weight-loss drug, the US Justice Department said on Tuesday. [21] Prosecutors say the two bought the fakes in China between July 2023 and April 2024 and sold them to US distributors at a discount. [21] The fakes came with packaging, leaflets and labels made to look real. [21] One pleaded not guilty after being sent from Italy; the other has not been caught. [21]

    Why it matters — The selling went on after the FDA seized some of the fakes in December 2023 and warned the public. [21] The charges carry up to 71 years in prison. [21]

17. 18

    Lawmakers press on an estrogen patch shortage

    The 96-member Democratic Women's Caucus in the US House wrote to Health Secretary Robert F. Kennedy Jr. on Monday about a long shortage of estrogen patches. [22] The patches deliver the hormone through the skin and ease menopause symptoms such as hot flushes and poor sleep. [22] Many women have had to cut or change their dose, or switch brands, Reuters has reported. [22] The FDA says it is working with all six makers to raise supply. [22]

    Why it matters — The lawmakers asked the FDA to consider adding the patches to its official shortage list, and wrote that a letter in July had produced no meaningful action. [22]

18. 19

    Drug industry picks Eric Cantor as its chief

    PhRMA, the lobbying group for the brand-name drug industry in the US, named Eric Cantor as its next chief executive. [11] Cantor is a former Republican majority leader of the US House of Representatives. [11] He starts on 9 November. [11] He arrives as the Trump administration tries to write into law its voluntary deals with more than two dozen companies to bring US medicine prices down to levels in similar countries. [11]

    Why it matters — He will face mounting pressure on drug prices from both main US parties, STAT notes. [11]

19. 20

    Lawmakers push back on a mailed-medicine rule

    A growing number of US lawmakers are urging the Trump administration to rethink a rule that takes effect next month. [20] It requires medicines mailed into the US from abroad to clear customs through a licensed customs broker, with a money guarantee called an entry bond. [20] Lawmakers fear it will stop Americans getting prescriptions from licensed pharmacies in other countries. [20] The extra steps could add costs that the person receiving the medicine has to pay. [20]

    Why it matters — It reaches anyone in the US who gets prescription medicine posted from a pharmacy abroad. [20]

20. 21

    New endometriosis tests, little proof yet

    Several start-ups now sell tests for endometriosis that use saliva, blood or electrical signals from the gut, The New York Times reported. [23] Endometriosis is a disease in which tissue like the womb lining grows outside the womb, and it affects at least one in ten women of child-bearing age. [23] Diagnosis takes seven to nine years on average and often needs surgery. [23] Experts say the evidence for the new tests comes from small studies. [23]

    Why it matters — The FDA has approved no test that avoids surgery, and some of these are sold for research only or through a loophole the FDA has failed to close. [23]

21. 22

    Zepbound may switch on fat burning, in mice

    Researchers at the University of Barcelona gave tirzepatide, the drug in Zepbound and Mounjaro, to obese mice. [24] They compared them with mice given no drug but fed the same amount of food. [24] The drug switched on brown fat, a kind of fat that burns energy instead of storing it. [24] That suggests the drug does more than cut appetite. [24] The finding is in mice and has not been tested in people. [24]

    Why it matters — Earlier drugs that switched on brown fat were held back by harm to the heart, and the researchers say tirzepatide does not have that effect. [24]

22. 23

    Stem cells behind a narrowing spine

    Researchers at Weill Cornell Medicine in New York found the stem cells that build the body's tendons and ligaments, they reported in the journal Cell on 7 September. [25] In lumbar spinal stenosis, thickened ligaments squeeze nerves in the lower back, causing pain and trouble walking, and it affects an estimated 103 million people. [25] People with the condition had more of these cells in their ligaments. [25] Turning down calcium signals inside the cells stopped the overgrowth in mice. [25]

    Why it matters — Calcium channel blockers, common blood-pressure pills, could one day be tested against it, though trials in people would come first. [25]

23. 24

    A search for drugs against heart scarring

    A team writing in Science, a major journal, tested about 4,000 known chemicals on heart cells grown from human stem cells. [26] They were looking for one that stops cardiac fibrosis, the scarring that stiffens the heart in heart failure. [26] No approved drug treats that scarring directly. [26] The best chemical blocks all three of the heart cells' receptors for adenosine, a natural signal, and it worked in mice with failing hearts. [26]

    Why it matters — Drugs that blocked only one of these receptors gave mixed results before. [26] The study found all three feed one shared signal inside the cell, so blocking all three works better. [26]

24. 25

    An old pill helps bladder cells kill hidden germs

    Researchers at EPFL, a Swiss university, studied OM-89, sold as Uro-Vaxom and used for decades to prevent repeat urinary infections. [27] E. coli bacteria can hide inside bladder cells, out of reach of antibiotics and the immune system. [27] In lab-grown bladder cells from mice and people, OM-89 strengthened the cells' own germ-destroying machinery and let more antibiotic in. [27] The study was published in PLOS Pathogens. [27]

    Why it matters — The results come only from lab models and do not change how the drug is approved for use, its maker OM Pharma says. [27]

25. 26

    Rare chemicals found in cannabis leaves

    Chemists at Stellenbosch University in South Africa analysed leaves from three commercially grown cannabis strains. [28] They found 79 phenolic compounds, a family of plant chemicals, and 25 of them had never been reported in cannabis. [28] Sixteen were tentatively identified as flavoalkaloids, a rare group never seen in the plant before. [28] Most of those turned up in just one strain. [28] The work appeared in the Journal of Chromatography A. [28]

    Why it matters — Cannabis leaves are often thrown away as waste. [28] Related plant chemicals interest drug researchers, but this study only identified the compounds and did not test what they do. [28]